| NEAT1 is overexpressed in prostate cancer, and drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription. | prostate, |
| The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. | prostate, |
| expression of NEAT1 in colorectal cancer may play an oncogenic role in colorectal cancer differentiation, invasion and metastasis | colorectal, |
| NEAT expression is associated with tumor recurrence and unfavorable prognosis in colorectal cancer. | colorectal, |
| Results show that NEAT1 regulated CDK6 expression in laryngeal squamous cell cancer (LSCC) cells which was mediated by miR-107; NEAT1 plays an oncogenic role in the tumorigenesis of LSCC. | laryngeal, |
| Its oncogenic activity is partially due to its repression of p21. and it may be a potential target for HCC therapy. | liver, |
| our study suggested that lncRNA NEAT1 plays an oncogenic role in NSCLC progression and provides potential mechanisms by which lncRNA NEAT1 contributes to this disease. | lung, |
| our current work revealed that the glioblastoma-associated lncRNA NEAT1 was an oncogenic factor that was regulated by EGFR pathway, promoting tumorigenesis by serving as a scaffold and recruiting the chromosome modification enzyme EZH2 to silence target-specific genes (Axin2, ICAT and GSK3B) to promote beta-catenin nuclear transport. | glioblastoma, |
| The author_s findings demonstrate that lncRNA NEAT1 acts as an oncogenic role in colorectal cancer cells by sponging miR-193a and may represent a potential marker for colorectal cancer patients. | colorectal, |
| Our findings on colorectal cancer (CRC) tissues, cell lines, and xenograft models overall support that NEAT1 serves as an oncogene, with knockdown attenuating CRC cell development. | colorectal, |
| NEAT1 conferred oncogenic role by regulating apoptosis and cell cycle progression in triple-negative breast cancer cells (TNBC). The knockdown of NEAT1 sensitized cells to chemotherapy, indicating the involvement in chemoresistance. shNEAT1 reduced stem cell populations such as CD44+/CD24-, ALDH+, and SOX2+, implicating that NEAT1 was closely related to cancer stemness in TNBC. | breast, |
| we suggest that NEAT1 exerts an oncogenic effect on melanoma development via inhibition of miR-495-3p and induction of E2F3. NEAT1 might serve as a crucial prognostic biomarker of melanoma. | skin, |
| NEAT1 is engaged in a negative feedback loop with p53 and thereby modulates cancer formation in mice by dampening oncogene-dependent activation of p53. Consistent with this finding, NEAT1 targeting sensitized established human cancer cells to both chemotherapy and p53 reactivation therapy. | None |
| NEAT1 exerts oncogenic effects in CCA. | None |
| Our results showed that NEAT1_1 plays an oncogenic role in DLBCL. NEAT1_1 expression may serve as a predictive marker for DLBCL patients. | None |
| NEAT1 functions as an oncogene influencing cell viability and invasion in part by serving as a competing endogenous RNA (ceRNAs) modulating miRNA-34a expression, leading to subsequent repression of the miR-34a/SIRT1 axis and activation of the Wnt/beta-catenin signaling pathway. | None |
| Authors showed that NEAT1 functions as an oncogenic sponge for the tumor suppressor microRNA-361 (miR-361), which suppresses proliferation, invasion, sphere formation and TX resistance by directly targeting the oncogene STAT3. | None |
| Long noncoding RNA NEAT1 functions as an oncogene in human laryngocarcinoma by targeting miR-29a-3p. | None |