| Results implicate SETD2 as a tumor suppressor gene and demonstrate that loss-of-function SETD2 mutations can facilitate the initiation and maintenance of leukemias with chromosomal translocations through a global reduction of H3K36me3. | leukemia, |
| Functional Studies on Primary Tubular Epithelial Cells Indicate a Tumor Suppressor Role of SETD2 in Clear Cell Renal Cell Carcinoma | kidney, |
| Our work defines SETD2 as a tumor suppressor gene in Hepatosplenic T-cell lymphoma (HSTL)and implicates genes including INO80 and PIK3CD in the disease | lymphoma, |
| Setd2 as a potent tumor suppressor in lung adenocarcinoma. | lung, |
| This study offers further evidence that SETD2 behaves like a tumour suppressor gene | None |
| SETD2 is a novel GIST tumour suppressor gene associated with disease progression. | None |
| SETD2, an epigenetic tumor suppressor: a focused review on GI tumor | None |
| Histone methyltransferase SETD2: a potential tumor suppressor in solid cancers | None |
| Canine osteosarcoma genomics identify SETD2 as a possible oncogenic driver of osteosarcoma, and findings establish the canine model as a useful comparative model for the corresponding human disease. | osteosarcoma, |