| The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein | leukemia, |
| Results implicate UHRF1 as an oncogene and suggest that global DNA hypomethylation induced by UHRF1 overexpression induces a p53-mediated senescence program that is bypassed in hepatocellular carcinoma. | liver, |
| our study demonstrated that UHRF1 played an oncogenic role in the progression of pancreatic cancer, and UHRF1 might be a promising target for the treatment of pancreatic cancer. | pancreatic, |
| Up-regulation of UHRF1 by oncogenic Ras promoted the growth, migration, and metastasis of pancreatic cancer cells. | pancreatic, |
| UHRF1 could act as a new oncogenic factor in ovarian cancer and be a potential molecular target for ovarian cancer gene therapy. | ovarian, |
| UHRF1 is an oncogene that promotes DNA hypomethylation. | None |
| K-Ras drives UHRF1 expression, establishing a novel link between this oncogene and Nrf2-mediated cellular protection. | None |
| results confirm that UHRF1 has oncogenic function in RCC and UHRF1 may promote tumor progression through epigenetic regulation of TXNIP | None |