| Review of downstream signaling molecules SLP-65 and Btk cooperating to limit proliferation and induce differentiation of pre-B cells, thereby acting as tumor suppressors to prevent pre-B cell leukemia. | leukemia, |
| SLP-65 regulates a developmental program that promotes differentiation and limits pre-B cell expansion, thereby acting as a tumor suppressor. | None |
| constitutive active Btk can substitute for SLP-65 as a tumor suppressor. | None |
| malignant transformation of Slp65(-/-) pre-B cells involves disruption of the p19(Arf)-Mdm2-p53 tumor suppressor pathway | None |
| Tumor suppressor BLNK is a target of transcriptional activation by PU.1 and Spi-B in the B cell lineage. | None |