| These results suggest that FOXA1 functions as a tumor suppressor through modulation of proliferation and migration of endometrial cancer cells. | endometrial, |
| FOXA1 is a tumor suppressor in endometrial cancer and has a possible interaction with estrogen receptor alpha. | endometrial, |
| As a tumor suppressor, FOXA1 targets PIK3R1 directly to inhibit PI3K/Akt signaling pathway, thus exerting a negative regulatory effect on proliferation, migration, and invasion of HCC in male patients. | liver, |
| FOXA1 may be associated with methylation of the tumor suppressor genes promoter in MCF-7 cell lines | None |
| FoxA1 as a lineage-specific oncogene in luminal type breast cancer. | breast, |
| Data show that FOXA1 may be an important oncogene in thyroid tumorigenesis and a potential new therapeutic target for the treatment of anaplastic thyroid cancers. | thyroid, |
| FOXA1 is a potential oncogene in anaplastic thyroid carcinoma. | thyroid, |
| the results of the present study suggested that FOXA1 is a potential oncogene in NSCLC | lung, |
| Findings suggested FOXA1 may act as an anti-oncogene in gastric cancer (GC) cells. Low-level expression of FOXA1 protein was confirmed in GC tissues and cell lines. FOXA1 over-expression could significantly affect cell proliferation, apoptosis and tumor invasion of GC cells, which may be resulted by reversing EMT. | gastric, |
| miR-760 should be considered as a tumor suppressor since it negatively regulates the oncogene protein FOXA1 and regulated TRAIL sensitivity in Non-small cell lung cancer cells. | lung, |
| FOXA1 is a master factor in controlling the TGF-beta-stimulated transcriptome and a regulator of TGF-beta biological functions in nasopharyngeal carcinoma oncogenesis. | nasopharyngeal,laryngeal, |
| Study find that FOXA1 is an important mediator of proliferative and antiapoptotic activities in human colorectal cancer cells. FOXA1 was upregulated in human colorectal cancer tissues and was associated with poor prognosis, suggesting an oncogenic role of FOXA1 in the development and progression of human colorectal cancer. | colorectal, |
| description of central role of FOXA1 in mediating oncogenesis driven by the androgen receptor, and mechanistic insights into how the classes of FOXA1 alteration promote the initiation and/or metastatic progression of prostate cancer; results have direct implications for understanding the pathobiology of other hormone-receptor-driven cancers and rationalize the co-targeting of FOXA1 activity in therapeutic strategies | prostate, |
| Our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells. | None |
| Foxa1 protein decreased the transcription activity of Proto-Oncogene Proteins c-bcl-2 promoter under normal conditions and oxidative stress. | None |
| Data indicate that FoxA1 regulates two distinct oncogenic processes via androgen receptor depnedent and independent pathways. | None |