| HNF4alpha maintains hepatocyte differentiation in the adult healthy liver, and its loss may directly contribute to hepatocellular carcinoma development, thus indicating this factor as a possible liver tumor suppressor gene. | liver, |
| critical for inhibition of hepatic proliferation, suggesting a novel role as a tumor suppressor | liver, |
| Nuclear receptor HNF4? performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence | prostate, |
| Correction: Nuclear receptor HNF4? performs a tumor suppressor function in prostate cancer via its induction of p21-driven cellular senescence | prostate, |
| GSK3beta chemical inhibition results in HNF4alpha DNA binding impairment while a constitutively active GSK3beta mutant impairs the TGFbeta-induced inhibitory effect on HNF4alpha tumor suppressor activity. | None |
| HNF4A exhibits oncogenic activity that affects the aggressiveness and angiogenesis of neuroblastoma through activating the transcription of MMP-14. | neuroblastoma, |