| The tumor suppressor gene, APC, is an independent prognostic parameter with poor outcome in breast cancer patients. | breast, |
| Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. | liver,cholangiocarcinoma, |
| Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma. | oral |
| The high frequency of methylation of the APC gene promoter suggests that the inactivation of tumor suppressor genes and of the genes related to the control of cellular proliferation through this mechanism is involved in gallbladder carcinogenesis. | bladder, |
| Apc tumor suppressor gene is the zonation-keeper of mouse liver. | liver, |
| The rs454886 snp in the APC tumor suppressor gene was associated with increased breast cancer risk. | breast, |
| GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. | colorectal, |
| Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. | testicular, |
| the promoter region is frequently hypermethylated in the APC and RASSF1A tumour suppressors in parathyroid tumours | thyroid, |
| Loss of the APC tumor suppressor gene causes upregulation of a DNA demethylase system; tissues taken from human subjects showed the demethylation of these same key developmental genes in human colon adenomas. | colorectal, |
| Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer. | endometrial, |
| Data show that tumor suppressor adenomatous polyposis coli (APC) loss results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating YAP (YY1-associated) protein (YAP) which are simultaneously up-regulated in the majority of colorectal cancer (CRC). | colorectal, |
| Utilizing zebrafish to examine the genetic relationship between MPC1 and Adenomatous polyposis coli (APC), a key tumor suppressor in colorectal cancer, the authors found that apc controls the levels of mpc1 and that knock down of mpc1 recapitulates phenotypes of impaired apc function including failed intestinal differentiation. | colorectal, |
| Studies suggest that both loss of tumor suppressive function and gain of function of APC mutants play critical roles in colorectal cancers (CRC) tumorigenesis. | colorectal, |
| The tumor suppressor protein APC colocalizes with beta-catenin in the colon epithelial cells. | colorectal, |
| Crystal structure of the amino-terminal coiled-coil domain of the APC tumor suppressor. | None |
| Asef, a link between the tumor suppressor APC and G-protein signaling. | None |
| Genomic rearrangements of the APC tumor-suppressor gene in familial adenomatous polyposis. | None |
| Apical membrane localization of the adenomatous polyposis coli tumor suppressor protein and subcellular distribution of the beta-catenin destruction complex in polarized epithelial cells. | None |
| Upstream stimulating factor-1 (USF1) and USF2 bind to and activate the promoter of the adenomatous polyposis coli (APC) tumor suppressor gene. | None |