| novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression | colorectal, |
| 15-PGDH is a direct downstream effector of HNF3beta and acts as a tumor suppressor in lung cancer. | lung, |
| Results demonstrate that 15-PGDH acts as a tumor suppressor in gastric cancer and provide further validation for 15-PGDH as a potential therapeutic target for gastric cancer. | gastric, |
| Demonstrate both downregulation and a tumor suppressor activity of 15-PGDH in gastric cancer. | gastric, |
| Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells | colorectal, |