| Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia. | leukemia, |
| The hematopoietic tumor suppressor interferon regulatory factor 8 (IRF8) is upregulated by the antimetabolite cytarabine in leukemic cells involving the zinc finger protein ZNF224, acting as a cofactor of the Wilms_ tumor gene 1 (WT1) protein | leukemia, |
| These findings identify IRF8 as a novel tumor suppressor regulating IFN-gamma/STAT1 signaling and beta-catenin signaling in breast cancer. | breast, |
| Identification of IRF8 as a potent tumor suppressor in murine acute promyelocytic leukemia | leukemia, |
| Interferon Consensus Sequence-Binding Protein 8, a Tumor Suppressor, Suppresses Tumor Growth and Invasion of Non-Small Cell Lung Cancer by Interacting with the Wnt/?-Catenin Pathway | lung, |
| IRF8 induces senescence of lung cancer cells to exert its tumor suppressive function. | lung, |
| IRF8 was identified as a functional tumor suppressor, which is frequently silenced by epigenetic mechanism in multiple carcinomas | None |
| Data demonstrate that IRF8 as a functional tumor suppressor is frequently methylated in RCC, and IRF8-mediated interferon signaling is involved in RCC pathogenesis. | None |