Sentence and cancer type

Showing 1-10 of 10 items.

Sentence	Cancertype
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response	glioma,
This article analyzes how different approaches have led to opposing conclusions and proffers a counterintuitive hypothesis that IDH1 mutation is intrinsically tumor suppressive in glioma but functionally undermined by the glutamate-rich cerebral environment, inactivation of tumor-suppressor genes and IDH1 copy-number alterations. REVIEW	glioma,
IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway	None
IDH1(R132H) is intrinsically tumor-suppressive but functionally attenuated by the glutamate-rich cerebral environment	None
data have identified a novel mechanism in which R132H mutation of the IDH1 gene serves as a tumor suppressor by promoting the recruitment of NK cells through CX3CL1/CX3CR1 chemotaxis.	None
IDH mutations promote gliomagenesis by disrupting chromosomal topology and allowing aberrant regulatory interactions that induce oncogene expression.	glioma,
Report a simple, non-germline murine intrahepatic cholangiocarcinoma model with activated Notch, loss of p53 and IDH1R132C mutation, supporting the oncogenic potential of IDH1R132C.	liver,cholangiocarcinoma,
IDH1 has oncogenic activity and a role in promoting leukemogenesis	None
Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate.	None
the mutant IDH1 protein is a stronger oncogene than R-2HG alone when comparable intracellular R-2HG levels are achieved	None