| Study determined that IGF1R is essential in tumor suppression in breast tumorigenesis. Attenuated IGF1R signaling in the MMTV-Wnt1 mouse mammary tumor model and in human breast cancer cell lines increases tumor epithelial cellular stress, resulting in upregulation of cytokine production promoting an aggressive tumor microenvironment through infiltration of immune cells and matrix remodeling. | breast, |
| Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis. | prostate, |
| Expression of IGF-1R is higher in esophageal squamous cell carcinoma than in adjacent normal tissue. In a xenograft model, results suggest the oncogenic function of IGF-1R in regulating cell proliferation, clonogenesis, the cell cycle and apoptosis. | esophageal, |
| Assessment of insulin-like growth factor 1 receptor as an oncogene in esophageal squamous cell carcinoma and its potential implication in chemotherapy. | esophageal, |
| the IGF1R oncogene which is an important regulator of MEK/ERK signaling pathway, was positively regulated by AFAP1-AS1 through ameliorating miR-133a-mediated IGF1R repression in pancreatic cancer tissues. | pancreatic, |
| Both IGF1R-Ras and RAGE-HMGB1 pathways may be involved in the oncogenesis of colorectal cancer in patients with type 2 diabetes. | colorectal, |
| Aberrant intracellular IGF-1R beta-subunit makes receptor knockout cells (IGF1R-/-) susceptible to oncogenic transformation. | None |
| tumors initiated by IGF-IR have the ability to become independent of this initiating oncogene, and IGF-IR independence is associated with characteristics consistent with an epithelial to mesenchymal transition | None |
| Reversal of oncogene transformation and suppression of tumor growth by the novel IGF1R kinase inhibitor A-928605. | None |
| The controlled release of miR-675 from H19 may also allow rapid inhibition of placental cell proliferation in response to cellular stress or oncogenic signals. | None |
| Effect of tyrosine mutations on the kinase activity and transforming potential of an oncogenic human insulin-like growth factor I receptor. | None |