| induces early apoptosis and has potential tumor suppressive effects in prostate cancer | prostate, |
| This study supports the role of IGFBP-1, -3 and -7 as potential tumour suppressor genes in human breast cancer. | breast, |
| Data indicate insulin-like growth factor (IGF)-binding protein-3 (IGFBP3) as a miR-21 target gene in glioblastoma and suggest that the oncogenic miRNA miR-21 down-regulates the expression of IGFBP3, which acts as a tumor suppressor in human glioblastoma. | glioblastoma, |
| IGFBP-3 has direct, IGF-independent inhibitory effects on angiogenesis providing an additional mechanism by which it exerts its tumor suppressive effects | None |
| Results showed that IGFBP-3 methylation played an important role in the silencing of its expression, suggesting that IGFBP-3 may act as a tumor suppressor gene in several human cancers examined. | None |