| Functional role for IRF-1 in the growth suppression of breast cancer cells and strongly implicate IRF-1 as a tumor suppressor gene in breast cancer that act to control apoptosis. | breast, |
| Data suggest that the dual effect of retinoids in increasing interferon regulatory factor-1 mRNA and nuclear protein may be essential for its tumor suppressor activity and immunosurveillance functions in breast epithelial cells. | breast, |
| Our findings strongly imply a tumor suppressor role for the IRF1 gene in breast cancer. | breast, |
| IRF-1 could be nominated as one of the tumor suppressor factors and could aid in the early detection of HCC.-e | liver, |
| IRF1 served as tumor suppressor in the regulation of cholangiocarcinoma cells proliferation, cell cycle, migration and invasion | cholangiocarcinoma, |
| Interferon Regulatory Factor 1 (IRF-1), a tumor suppressor and an antiviral host factor, selectively suppresses an endogenous retroviruses (ERVs) expression. IRF-1 suppresses endogenous reverse transcriptase activity of interferon-beta treated primary macrophages and mouse embryonic fibroblasts. Specific ERV expression is suppressed in both lung and spleen of IRF-1-/- mice. | lung, |
| Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer. | gastric, |
| The tumor suppressor interferon regulatory factor 1 interferes with SP1 activation to repress the human CDK2 promoter. | None |
| a novel tumor necrosis factor (ligand) superfamily, member 10-mediated tumor suppressor activity of interferon regulatory factor 1 and suggest a mechanistic basis for the synergistic antitumor activities of certain retinoids and interferons | None |
| a novel repressor domain and differential gene regulation may contribute to IRF-1 tumor suppressor activity | None |
| Cooperative regulation of the interferon regulatory factor-1 tumor suppressor protein by core components of the molecular chaperone machinery. | None |
| Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP. | None |
| A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1. | None |
| STAT1/IRF1 is a key growth inhibitory and tumor suppressive signaling pathway that prevents mammary cancer formation by maintaining growth control. | None |
| The gammaherpesvirus-driven germinal center expansion was exaggerated and lost its transient nature in the absence of interferon-regulatory factor 1 (IRF-1), a transcription factor with antiviral and tumor suppressor functions. | None |