| Ack1 activated by surface signals or oncogenic mechanisms may directly enhance AR transcriptional function and promote androgen-independent progression of prostate cancer. | prostate, |
| To ascertain whether cell autonomous androgen receptor is essential for initiation of prostate intraepithelial neoplasia, the response of AR-null prostate epithelia to paracrine and cell autonomous oncogenic signals was assessed in vivo. | prostate, |
| Minireview: The androgen receptor in breast tissues: growth inhibitor, tumor suppressor, oncogene?. | breast, |
| On the basis of the aforementioned evidence, we postulate that AR exhibits oncogenic properties in gastric cancer via several possible mechanisms, which may partly explain the higher prevalence of gastric cancer among males. | gastric, |
| Results suggest that the AR and miR-21 axis exerts its oncogenic effects in prostate tumors by downregulating TGFBR2, hence inhibiting the tumor-suppressive activity of TGFbeta pathway. | prostate, |
| USP12 deubiquitinates MDM2 and AR, which in turn controls the levels of the TP53 tumour suppressor and AR oncogene in prostate cancer. | prostate, |
| AR-Vs, such as AR-V7, have been associated with unfavourable clinical outcomes in patients; however, attempts to specifically inhibit or prevent the formation of AR-Vs have, to date, been unsuccessful. Thus, novel therapeutic strategies are desperately needed to address the oncogenic effects of AR-Vs, which can drive lethal forms of prostate cancer. | prostate, |
| HORAS5 is a novel, targetable mediator of castration-resistant prostate cancer through its essential role in the maintenance of oncogenic AR activity. | prostate, |
| Data highlight that loss of AR-mediated growth suppression is an independent process, and that, without additional changes, is insufficient for acquiring oncogene addiction to AR signaling. | None |