| The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. | None |
| T-cell-specific human ITK-Syk oncogene in mice leads to early polyclonal T cell lymphoproliferation with B cell expansion. It induces terminal T cell differentiation via Blimp-1, eliminating oncogene-expressing cells early in development. | None |
| Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk. | None |
| Loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including beta-human papillomavirus and Epstein-Barr virus. | None |