| A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection. | None |
| Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: might dog be used as a model for human disease?. | None |
| The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. | None |
| The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer. | None |
| Human PDGFA receptor gene maps to the same region on chromosome 4 as the KIT oncogene. | None |
| Data show that PI3 kinase is an attractive therapeutic target in malignancies induced by proto-oncogene protein c-Kit mutations. | None |
| PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner. | None |
| Retinoic acid triggers c-kit gene expression in spermatogonial stem cells through an enhanceosome constituted between transcription factor binding sites for retinoic acid response element (RARE), spleen focus forming virus proviral integration oncogene (SPFI1) (PU.1) and E26 transformation-specific (ETS). | None |
| Data characterized metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) genetic susceptibility genes beyond kit proto-oncogene protein (KIT)/PDGF alpha receptor (PDGFRalpha) genotype. | None |
| Studies indicate that microRNAs as important regulators of proto-oncogene protein c-kit expression. | None |
| Different types of cancers harbor mutations in the oncogene KIT | None |
| Data show that a heterozygous missense mutation, c.2585T>C, was identified in exon 18 of the proto-oncogene protein c-kit (KIT) gene. | None |
| Our KitD814V-triggered B-ALL mouse model might prove valuable for the identification of additional oncogenic mutations and mechanisms that may contribute to leukemogenesis in humans. | None |
| A HindIII RFLP demonstrated for the kit oncogene on chromosome 4. | None |
| Study shows that the bone marrow-derived mast cells hyperproliferation caused by loss of Tet2 is significantly related to hyperactivation of the PI3K pathway and that activating KIT mutation-induced ligand-independent growth utilizes a similar pathway. Cells that express oncogenic KIT and lack TET2 are also dependent on the PI3K pathway for proliferation. | None |
| The current study shows that SH3BP2 is expressed in primary tumors and cell lines from Gastrointestinal stromal tumors (GISTs) patients and that SH3BP2 silencing leads to a downregulation of oncogenic KIT and PDGFRA expression and an increase in apoptosis in imatinib-sensitive and imatinib-resistant GIST cells. | None |
| A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. | None |
| miR-155 drives oncogenesis by promoting and cooperating with mutations in the c-Kit oncogene | None |
| RUNX1 regulates the oncogene KIT, by binding to its enhancer, and through interaction with FUBP1. | None |
| Circulating tumor DNA (CtDNA) harboring tumor-specific c-Kit protooncogene (cKIT) or platelet derived growth factor receptor alpha (PDGFRA) mutations was detected in in gastrointestinal stromal tumor (GIST). | None |