| The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-kappaB and RalB signaling pathways. | pancreatic, |
| Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma. | colorectal, |
| pancreatic ductal cells, whereas exhibiting relative resistance to oncogenic Kras alone, can serve as an effective cell of origin for pancreatic ductal adenocarcinoma in the setting of gain-of-function mutations in p53 | pancreatic, |
| KRAS-E2F1-ILK-hnRNPA1 regulatory loop enables pancreatic cancer cells to promote oncogenic KRAS signaling and to interact with the tumor microenvironment to promote aggressive phenotypes. | pancreatic, |
| Results show that oncogenic KRAS can activate Rho through miR-31-mediated regulation of RASA1 indicating miR-31 acts as a KRAS effector to modulate invasion and migration in pancreatic cancer. | pancreatic, |
| In operated pancreatic adenocarcinoma, incidence of mutations was: Kirsten rat sarcoma viral oncogene homolong (KRAS) = 87%. | pancreatic,sarcoma, |
| Expression of ras p21 oncogene product on human bladder tumors. | bladder, |
| As a consequence, Slug transcription is down-regulated relieving A549 cells from Slug-mediated repression of E-cadherin transcription, thereby diminishing the metastatic potential of these oncogenic Ras-expressing NSCLC cells | lung, |
| findings demonstrate that advanced gastric tumorigenesis requires oncogenic KRAS or BRAF in concert with aberrant STAT3 activation in epithelial precursor cells of the glandular stomach | gastric, |
| [Immunohistochemical studies of ras oncogene product p21 in human ovarian tumors]. | ovarian, |
| Activation of the K-ras oncogene in liver tumors of Hudson River tomcod. | liver, |
| We also uncovered that Prox1-heterozygosis markedly increases the formation of acinar-to-ductal-metaplasias and early neoplasias, and enhances features associated with inflammation, in mouse pancreatic tissues expressing oncogenic Kras. | pancreatic, |
| c-Myc is a driver when combined with kRas/Akt3 oncogenic signals in gliomagenesis, whereas Cdc20 overexpression is a passenger | glioma, |
| Study shows that during the development and progression of pancreatic cancer, oncogenic KRas causes metabolic changes that lead to increased generation of mitochondrial reactive oxygen species. | pancreatic, |
| The rs61764370 Functional Variant in the KRAS Oncogene is Associated with Chronic Myeloid Leukemia Risk. | leukemia, |
| Reduced insulin receptor substrate-1 (IRS-1) staining in lung adenocarcinoma tissue microarray displayed a significant survival disadvantage, especially within the Kirsten rat sarcoma viral oncogene homolog (KRAS) mutant subgroup. | sarcoma,lung, |
| miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression | colorectal, |
| these results describe a novel mechanism governing PRKD1 gene expression in pancreatic ductal adenocarcinoma and provide a functional link between oncogenic KRas, NF-kappaB and expression of PRKD1. | pancreatic, |
| ConclusionThe significantly higher frequency of codon 61 mutation of the ras oncogene in primary and bilateral pterygium specimens compared with normal conjunctiva supports the tumoral origin of pterygium | oral |
| oncogenic KRas-induced increase in fluid-phase endocytosis has a key role during cellular transdifferentiation in pancreatic acinar cells. This result supports emerging evidence for endocytosis playing a crucial role in regulating the signaling output of the cells | pancreatic, |