| KRAS mutational testing in the selection of patients for EGFR-targeted therapies. | None |
| the presence of mutations in the KRAS oncogene can be used to predict which patients are unlikely to benefit from treatment with epidermal growth factor receptor-directed therapy. | None |
| Epithelial cells expressing oncogenic K-Ras showed increased proliferation mediated through COX-2-dependent activation of beta-catenin signaling and inhibition of apoptosis. | None |
| oncogenic KRAS could cause the accumulation of phosphatidylinositides and modulate the cell shape and migration. | None |
| activation of PIK3CA may be an important molecular event contributing to the maintenance of OSE transformation initiated by oncogenes such as K-ras | None |
| studies show that, in addition to inhibiting replicative senescence, Ndy1 inhibits Ras oncogene-induced senescence via a similar molecular mechanism | None |
| The expression of Vitamin D3 up-regulated protein 1 is upregulated by oncogenic Ras in endothelial cells, mediating ROS generation. | None |
| Relationship of p21-activated kinase (PAK) and filopodia to persistence and oncogenic transformation. | None |
| Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression. | None |
| Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. | None |
| A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. | None |
| These findings point to a previously underappreciated role of Ras in mitotic progression and demonstrate that mitotic stress induced by the Ras oncogene. | None |
| Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells. | None |
| upregulation of Atg5 is required for the oncogenic H-ras-induced autophagic cell death in normal fibroblasts and that activation of Rac1/MKK7/JNK-signaling pathway leads to upregulation of Atg5 in response to oncogenic H-ras | None |
| genetic ablation of the receptor for chemokines, mCXCR2, reduced oncogenic Ras-driven tumorigenesis in mice | None |
| Some neuronal properties of PC12 cells differentiated by the K-ras oncogene. | None |
| Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. | None |
| Suppression of TBK1 induced apoptosis specifically in human cancer cell lines that depend on oncogenic KRAS expression | None |
| A subpopulation of Pdx1-expressing cells is susceptible to oncogenic K-Ras-induced transformation without tissue injury, whereas insulin-expressing endocrine cells are completely refractory to transformation under these conditions. | None |
| Aurora-A may converge upon oncogenic Ras signaling through RalA. | None |