| Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion. | None |
| Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins. | None |
| Oncogenic K-Ras and its effector Raf1 convert death receptors into invasion-inducing receptors by suppressing the ROCK/LIM kinase pathway, and this is essential for K-Ras/Raf1-driven metastasis formation. | None |
| Results of the current study confirm the cumulative effect of Apc loss and oncogenic KRAS activation on intestinal tumorigenesis. | None |
| Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. | None |
| Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells. | None |
| Tissue-specific p19Arf regulation dictates the response to oncogenic K-ras. | None |
| Authors used a mouse model in which an oncogenic allele of K-ras is activated and Notch1 is deleted in the pancreas. Loss of Notch1 in this model resulted in increased tumor incidence implying that Notch1 functions as a tumor suppressor gene in PDAC. | None |
| GTPase domains of ras p21 oncogene protein and elongation factor Tu: analysis of three-dimensional structures, sequence families, and functional sites. | None |
| data identify the downregulation of Clast1/LR8 as a potentially important mechanism by which oncogenic Ras-mediated neoplastic transformation occurs | None |
| Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin d1/cdk4 and nek2. | None |
| Proto-oncogenic H-Ras, K-Ras, and N-Ras are involved in muscle differentiation via phosphatidylinositol 3-kinase. | None |
| The proto-oncogenic k-Ras is directly involved in the promotion of muscle differentiation via PI3K and its downstream signaling pathways. | None |
| Results provide the first genetic demonstration that MKK4 is essential to mediate the oncogenic effect of Ras in vivo. | None |
| Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract. | None |
| Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases. | None |
| Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. | None |
| Results reveal an unexpected role for WT1 as a key regulator of the genetic network of oncogenic KRAS and provide important insight into the mechanisms that regulate proliferation or senescence in response to oncogenic signals. | None |
| Data reveal that HIF-1alpha and HIF-2alpha work together to modulate cancer metabolism and regulate genes signature overlapping with oncogenic KRAS. | None |
| autophagy is critically involved in malignant transformation by oncogenic K-Ras and show that reactive oxygen species-mediated JNK activation plays a causal role in autophagy induction through up-regulation of ATG5 and ATG7. | None |