| RhoB has a role as a tumor suppressor in lung neoplasms | neoplasm,lung, |
| Sudy demonstrates that RhoB expression is frequently downregulated in non-small-cell lung cancer (NSCLC) by multiple mechanisms, suggesting that RhoB is a candidate tumor suppressor gene for NSCLC. | lung, |
| appears that RhoB plays an opposing role from that of RhoA and/or RhoC in gastric cancer cells. Our work suggests that RhoB may play a tumor suppressor role and subsequently may have potential implications in future targeted therapy | gastric, |
| miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells. | colorectal, |
| RhoB may play a tumor suppressive role in clear cell renal cell carcinoma cells | kidney, |
| MicroRNA-19a and microRNA-19b promote the malignancy of clear cell renal cell carcinoma through targeting the tumor suppressor RhoB | kidney, |
| Farnesyltransferase inhibitors recruit the antioncogenic RhoB-GG protein to interfere with signaling by pro-oncogenic Rho proteins, possibly by sequestering common exchange factors or effectors such as PRK that are important for cell transformation. | None |
| miR-21 promotes multiple components of the metastatic phenotype in vitro by regulating several important tumor suppressors, including RHOB. | None |
| In cancer cells in vitro or in vivo, RhoB functions as a tumor suppressor that restricts EGF receptor (EGFR) cell surface occupancy as well as Akt signaling | None |