| LOX-mRNA level in both cell lines and tissues of HNSCC was markedly reduced as opposed to benign keratinocyte cell lines and mucosal tissue samples of the upper aerodigestive tract suggesting that LOX is involved in tumor suppressive processes. | HNSC, |
| LOX is a tumor suppressor gene inactivated by methylation and loss of heterozygosity in gastric cancers, and possibly also in other cancers. | gastric, |
| BCL2 repression by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells | pancreatic,lung, |
| Genetic polymorphism as a mechanism of impaired tumor suppressor function of LOX-propeptide and it may play an etiologic role in ER-negative breast cancer. | breast, |
| Anti-oncogenic effects of lysyl oxidase on ras-mediated transformation are due to its ability to inhibit signaling pathways that lead to activation of NF-kappa B | None |
| Demonstration of in vitro interaction between tumor suppressor lysyl oxidase and histones H1 and H2: definition of the regions involved. | None |
| the interaction of LOX-PP with Hsp70 and c-Raf inhibits a critical intermediate in Ras-induced MEK signaling and plays an important role in the function of this tumor suppressor | None |
| LOX displays tumor suppressor activities | None |