| While Lrp5 in tumor cells acts as a tumor promoter in Wnt /?-catenin signaling that is considered a therapeutic target [28,29], the result in this study indicates that Lrp5 in osteocytes serves as a tumor suppressor. | breast |
| It has been demonstrated that LRP5 and 6 are potential oncogenic proteins. | unknown |
| Thus, our results suggest that the Lrp5/?-catenin axis activates tumor-promoting signaling in tumor cells but tumor-suppressive signaling in osteocytes. | unknown |