| Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. | laryngeal, |
| Data show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. | lung, |
| Epigenetic down-regulation of the tumor suppressor gene PRDM1/Blimp-1 in diffuse large B cell lymphomas: a potential role of the microRNA let-7. | lymphoma, |
| Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc. | kidney, |
| let-7 is a tumor suppressor that negatively regulates RAS, also in Ewing Sarcoma, and HIF-1alpha may contribute to the aggressive metastatic behavior of Ewing Sarcoma | sarcoma, |
| Let-7c-5p acted as a tumor suppressor in breast cancer possibly by negatively regulating ERCC6. | breast, |
| Circulating miRNA let-7 levels are markedly reduced in breast cancer patients and highly correlate with metastases development implying an important role of miRNA let-7 as a tumor suppressor. | breast, |
| Results show that Let-7a-5p induced G1-phase cell cycle arrest in lung cancer cells. Let-7a-5p directly targeted the 3_UTR of CCND1 to inhibit its expression. These data suggest that let-7a- 5p act as a tumor suppressor by regulating cell cycle via CCND1 expression. | lung, |
| let-7a functions as a tumor suppressor by targeting MAGE-A1 in breast cancer | breast, |
| The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| Data demonstrate that miR-107 negatively regulates the tumor suppressor miRNA let-7 via a direct interaction. | None |
| let-7a acts as a tumor suppressor in RCC cell lines by down-regulating c-myc and c-myc target genes. | None |
| The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition | None |