| study identifies let-7b as a tumor suppressor that represses cancer cell proliferation and migration as well as tumor metastasis in mouse melanoma cells. | skin, |
| let-7b may directly target Cthrc1 and function as a tumor suppressor gene in gastric cancer. | gastric, |
| Let-7b might function as a tumor suppressor in papillary thyroid carcinoma by suppressing the expression of high-mobility group A2, and therefore might provide a promising therapeutic target for patients with papillary thyroid carcinoma. | thyroid, |
| Indirect Down-regulation of Tumor-suppressive let-7 Family MicroRNAs by LMO1 in Neuroblastoma | neuroblastoma, |
| Let-7b acts as a tumor suppressor in osteosarcoma via targeting IGF1R | osteosarcoma, |
| The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| the loss of let-7b in aggressive tumors may drive tumorigenesis by up-regulation of Aurora B and other targets of the miRNA, which further supports the role of let-7b in tumor suppression. | None |