| Results indicate that microRNA let-7c is downregulated in prostate cancer (PCa) and functions as a tumor suppressor, and is a potential therapeutic target for PCa. | prostate, |
| The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| Our results demonstrated that overexpressed CDK4 is an unfavorable prognostic factor which suppresses the expression of tumor suppressive-factor let-7c through p21/CCND1/CDK6/E2F1 signaling | None |