| Data indicate that LASP1 may have an oncogenic function and that it might be regulated by miR-1, miR-133a, and miR-218, which may function as tumor suppressive miRNAs in bladder cancer (BC). | bladder, |
| MiR-1 is a tumor suppressor in thyroid carcinogenesis targeting CCND2, CXCR4, and SDF-1alpha. | thyroid, |
| these data indicated that tumor suppressive miR-1 induces apoptosis through direct inhibition of SRSF9 in bladder cancer. | bladder, |
| Findings indicate that miR-1 acts as a tumor suppressor in prostate cancer by influencing multiple cancer-related processes and by inhibiting cell proliferation and motility. | prostate, |
| miR-1 can have a tumor suppressor function in colorectal cancer by downregulating MET oncogene both at RNA and protein level and that reexpression of miR-1 leads to MET-driven reduction of cell proliferation. | colorectal, |
| Suggest that miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer. | bladder, |
| This study provides evidence for hsa-miR-1 to play tumor suppressive roles via downregulating lncRNA UCA1 in bladder cancer | bladder, |
| MiR-1 acts as a tumor suppressor by inhibiting angiogenesis-related growth factors in human gastric cancer | gastric, |
| miR-1 is downregulated in ovarian cancer tissues, and may play a tumor suppressive role by inhibiting c-Met expression and its effects on the regulation of cell proliferation, migration and invasion | ovarian, |
| Further studies verified that miR-1 regulates EMT signalling pathways directly through Notch2. Therefore, these results confirm that, as a tumor suppressor gene, miR-1 may be a potential tumor marker for the early diagnosis of esophageal squamous cell carcinoma and a new drug target. | esophageal, |
| Data show that miR-1 is tumor suppressive miRNA in glioblastoma (GBM). miR-1 is expressed at relatively low levels in GBM, and high miR-1 expression is associated with better patient survival in glioma. Its ectopic expression in GBM cells inhibited cell proliferation and migration. Expression of miR-1 in GBM cell lines directly targets fibronectin. | GBM,glioblastoma,glioma, |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| Taken together, our findings established a tumor suppressive role for miR-1 in the progression of ccRCC by targeting CDK4, CDK6, Caprin1 and Slug and suggested miR-1 can be served as a novel potential therapeutic target for ccRCC. | None |