| miR-122, a tumor suppressor microRNA affecting hepatocellular carcinoma intrahepatic metastasis by angiogenesis suppression, exerts some of its action via regulation of ADAM17. | liver, |
| There is a double-negative feedback loop between a tumor suppressor (miR-122) and an oncogene (c-Myc) in hepatocellular cancer. | liver, |
| miR-122*, the passenger strand of miR-122, regulates the activity of p53 by targeting Mdm2. Importantly, similarly to miR-122, miR-122* is significantly down-regulated in human hepatocellular carcinoma. We therefore propose that miR-122* is an important contributor to the tumor suppression activity previously attributed solely to miR-122 | liver, |
| Our study also reveal that miR-122 may function as a tumor suppressor in childhood acute myeloid leukemia | leukemia, |
| miR-122 is the dominant miRNA in the liver and a known tumor suppressor. The findings suggest a role for circulating miR-122 in the maintenance of vascular endothelial cells and in the prevention of Cancer. | liver, |
| miR-122-5p was significantly downregulated in nasopharyngeal carcinoma (NPC) cell lines. Additionally, it was demonstrated that special AT-rich sequence-binding protein 1 (SATB1) was targeted by miR-122-5p. Results revealed that miR-122-5p inhibits cell proliferation, colony formation, cell migration and cell invasion by targeting SATB1. Data suggested that miR-122-5p functions as a tumor suppressor in NPC. | colorectal,nasopharyngeal,laryngeal, |
| data indicate that up-regulation of miR-122 promotes cell survival in acquired radioresistant breast cancer and also suggest that miR-122 differentially controls the response to radiotherapy by a dual function as a tumor suppressor an and oncomiR dependent on cell phenotype. | breast, |
| MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers. | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| Results demonstrate that miR-122 functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting IGF1. | None |
| MiR-122 functions as a tumor suppressor by inhibiting proliferation and inducing apoptosis, which is achieved by directly targeting RUNX2. | None |
| The data demonstrate a novel phosphorylation-dependent mechanism to regulate Gld2 activity, revealing tumour suppressor miRNAs(miR-122) as a previously unknown target of Akt1-dependent signalling | None |