| miR-126&126* restored expressions play a tumor suppressor role by directly regulating ADAM9 and MMP7 in melanoma. | skin, |
| Results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies. | colorectal, |
| Study indicates that miR-126 is a tumor suppressor that inhibits gastric cancer cells proliferation by targeting PI3KR2, Crk and PLK2. | gastric, |
| Results show that in esophageal squamous cell carcinoma (ESCC), miR-126 was downregulated and IRS-1 and GOLPH3, overexpressed suggesting a tumor suppression role of miR-126 via the regulation of IRS-1 and GOLPH3. | esophageal, |
| Our results suggest that miR-126 might play tumor-suppressive and miR-200c an oncogenic role in non-small cell lung cancer | lung, |
| our study suggests that miR-126 functions as a potential tumor suppressor in esophageal squamous cell carcinoma progression via regulating PI3K/AKT signaling pathway partly by targeting PIK3R2 | esophageal, |
| miR-126 may act as a tumor suppressor via inhibition of cell invasion by downregulating ADAM9 in breast cancer development. | breast, |
| miR-126 functions as a tumor suppressor in glioma cells by targeting IRS-1 expression via the PI3K/AKT signaling pathways | glioma, |
| The modulatory role of miR-126 on expression of VEGF-A and its tumor suppressive roles were demonstrated for the first time in thyroid cancer | thyroid, |
| Results indicate that miR-126 acts as a tumor suppressor by inactivating RhoA signaling via CXCR4 in colon cancer. | colorectal, |
| Loss of tumor suppressor miR-126 contributes to the development of hepatitis B virus-related hepatocellular carcinoma metastasis through the upregulation of ADAM9 | liver, |
| miR-126 Functions as a Tumor Suppressor by Targeting SRPK1 in Human Gastric Cancer | gastric, |
| Data demonstrate the tumorigenic role of Lnc-ATBs in endometrial cancer via abrogation of tumor suppressor miR-126 signals. | endometrial, |
| miR-126 functions as a tumor suppressor in cervical cancer cells in vitro, which inhibits the proliferation, migration and invasion by suppressing MMP2, MMP9 expression and inactivating JAK2/STAT3 signaling pathway through targeting ZEB1 | cervical, |
| Study found miR-126 to be significantly down-regulated in the dabrafenib-resistant myeloma tumors and cell lines. Additional results confirm the tumor suppressor role of miR-126-3p in melanoma and demonstrates that its down-regulation is involved in acquired resistance to dabrafenib. | skin, |
| Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| the lack of miR-126 expression in atypical lymphocytes is in keeping with recent findings that miR-126 functions as a tumor suppressor in hematological cancers such as AML. | None |
| our data revealed that miR-126 functions as a tumor suppressor in CRC cells by regulating CXCR4 expression via the AKT and ERK1/2 signaling pathways and might be a novel target for therapeutic strategies in CRC. | None |
| miR-126-5p could directly target PTHrP and have a tumor suppressor function in giant cell tumor. | None |