| MicroRNA-130b functions as a tumor suppressor by regulating RUNX3 in epithelial ovarian cancer | ovarian, |
| MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer. | colorectal, |
| Study showed that miR-130b was significantly upregulated in Bladder cancer (BCa) and may play an oncogenic role in BCa occurrence and development by targeting VGLL4. | bladder, |
| miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation, which would be helpful in developing miRNA-based treatments for ESCC. | None |
| Our functional assays revealed that miR-130b-5p significantly blocked the malignant abilities of PDAC cell lines (PANC-1 and SW1990), e.g., cancer cell proliferation, migration, and invasion. A total of 103 genes were identified as possible oncogenic targets by miR-130b-5p regulation in PDAC cells based on genome-wide gene expression analysis and in silico database search | None |
| The expression of miR-130b was upregulated in RCC. miR-130b promoted cell growth and was associated with sunitinib resistance through regulating PTEN expression. Collectively, these results suggest that miR-130b may play an oncogenic role and be a promising therapeutic target. | None |