| acts as a liver tumor suppressor | liver, |
| miR-140-5p acts as a tumor suppressor during ovarian carcinogenesis, inhibiting ovarian cancer growth partially by repressing PDGFRA expression. | ovarian, |
| Study showed downregulation of miR-140 in colorectal cancer (CRC) closely associated with overall survival. VEGFA, its target, is up-regulated in CRC cells suggesting a tumor suppressive role of miR-140-5p in CRC and progression by targeting VEGFA. | colorectal, |
| The highly expressed 5_isomiR of hsa-miR-140-3p contributes to the tumor-suppressive effects of miR-140 by reducing breast cancer proliferation and migration | breast, |
| In osteosarcoma cells, miR-140 acts as a tumor suppressor by targeting HDAC4. | osteosarcoma, |
| miR-206 and miR-140, as tumor suppressors, induced lung adenocarcinoma cell death and inhibited cell proliferation by modifying oncogenic TRIB2 promoter activity through p-Smad3. | lung, |
| miR-140-3p functions as a tumor suppressor in squamous cell lung cancer by regulating BRD9 | lung, |
| Our results demonstrate that miR-140 acts as a tumor suppressor in breast cancer by inhibiting FEN1 to repress DNA damage repair and reveal miR-140 to be a new anti-tumorigenesis factor for adjunctive breast cancer therapy. | breast, |