| miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation. | colorectal, |
| Small RNA sequencing and functional characterization reveals MicroRNA-143 tumor suppressor activity in liposarcoma. | sarcoma, |
| miR-143 functions as a tumor suppressor in MLL-AF4 B-cell acute lymphoblastic leukemia. | leukemia, |
| Findings provide clues regarding the role of the miR-143/145 cluster as a tumor suppressor in breast cancer through the inhibition of ERBB3 translation. | breast, |
| The miR-143/145 cluster acts as a tumor suppressor in colorectal cancer through the inhibition of IGF1R translation. | colorectal, |
| Decreased microRNA-143 expression and its tumor suppressive function in human oral squamous cell carcinoma | oral |
| MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer | prostate, |
| MiR-143 enhanced the tumor suppressive effect of shikonin partly through the regulation of BAG3 in glioblastoma stem cells. | glioblastoma, |
| MiR-143-3p functions as a tumor suppressor by regulating cell proliferation, invasion and epithelial-mesenchymal transition by targeting QKI-5 in esophageal squamous cell carcinoma | esophageal, |
| present studies highlight miR-143 as a tumor suppressor in oral squamous cell carcinoma (OSCC) by the suppression of cell migration, glucose metabolism and proliferation through directly targeting HK2, rendering miR-143 a therapeutic strategy for the treatment of clinical OSCC patients. | oral |
| MiR-143 acts as a tumor suppressor in pancreatic ductal adenocarcinoma through directly targeting TAK1. | pancreatic, |
| miR-143-3p acts as a novel tumor suppressive miRNA by regulating gastric tumor growth, migration and invasion through directly targeting AKT2 gene | gastric, |
| Collectively, these results demonstrate that miR-143-3p could represent at the same time, a new early diagnostic marker and therapeutic target acting as tumor suppressor in melanoma cancer. | skin, |
| MicroRNA-143 shows tumor suppressive effects through inhibition of oncogenic K-Ras in pituitary tumor | pituitary, |
| The miR-143/145 Cluster, a Novel Diagnostic Biomarker in Chondrosarcoma, Acts as a Tumor Suppressor and Directly Inhibits Fascin-1 | sarcoma, |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| findings suggest that the chemically-modified synthetic miR-143 functions as a tumor suppressor in T24 cells by targeting ERK5 and/or Akt | None |
| Loss of the tumor-suppressive miR-143/145 cluster enhanced cancer cell migration and invasion in PCa through directly regulating GOLM1. | None |
| Expression of oncogenic miR-17-92 and tumor suppressive miR-143-145 clusters in basal cell carcinoma and cutaneous squamous cell carcinoma | None |
| study demonstrates that miR-143 and -145 have functional properties and expression patterns typical for tumor suppressors, but the function is influenced by cellular factors such as cell type and miRNA cotransfection | None |