| Data show that IGF-IR resistant to miR145 is not down-regulated by miR145 but fails to rescue colon cancer cells from growth inhibition, and indicate that down-regulation of IRS-1 plays a significant role in the tumor suppressor activity of miR145. | colorectal, |
| we described a tumor suppression function of miR-145 in breast cancer cell lines, and we linked miR-145 to TP53 and ER-alpha | breast, |
| miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer. | bladder, |
| These findings suggest that miR-145 acts as a tumor suppressor in both canine and human malignant melanomas. | skin, |
| this study suggests that miR-145 modulates ovarian cancer growth and invasion by suppressing p70S6K1 and MUC1, functioning as a tumor suppressor. | ovarian, |
| Validated that miR-145 targets two oncogenes, ANGPT2 and NEDD9, and some others in Renal Cell Carcinoma. Findings show that miR-145 functions as tumor suppressor in RCC, suggesting that miR-145 may be a potential therapeutic target for RCC. | kidney, |
| miR-145 might act as a tumor suppressor in uveal melanoma, and downregulation of the target IRS-1 might be a potential mechanism. | skin, |
| Suggest that miR-1 and miR-145 act as tumor suppressor microRNAs in gallbladder cancer. | bladder, |
| MIR145a acts as a tumor suppressor in melanoma. | skin, |
| Findings provide clues regarding the role of the miR-143/145 cluster as a tumor suppressor in breast cancer through the inhibition of ERBB3 translation. | breast, |
| The miR-143/145 cluster acts as a tumor suppressor in colorectal cancer through the inhibition of IGF1R translation. | colorectal, |
| The role of Mir-145 in glioma cell progression and its mechanisms of action:miR145 is a tumor suppressor which inhibits glioma cell proliferation, invasion and angiogenesis. | glioma, |
| miR-145 functions as a tumor suppressor in nasopharyngeal carcinoma progression via targeting FSCN1. | nasopharyngeal,laryngeal, |
| Tumor suppressor miR-145 reverses drug resistance by directly targeting DNA damage-related gene RAD18 in colorectal cancer | colorectal, |
| Low expression of microRNA-145 in patients with malignant bone tumors may be involved in cell proliferation and invasion of malignant bone tumors like osteosarcoma as a tumor suppressor. | osteosarcoma, |
| these data suggested that miR-145 plays a pivotal role in colon cancer through inhibiting cell proliferation migration and invasion, and miR-145 may serve as a tumor suppressor by targeting paxillin gene. | colorectal, |
| MiR-145 functions as a tumor suppressor targeting NUAK1 in human intrahepatic cholangiocarcinoma. | liver,cholangiocarcinoma, |
| these findings indicate that miR-145 acts as a tumor suppressor and its downregulation in tumor tissues may contribute to the progression and metastasis of hepatocellular carcinoma (HCC)through a mechanism involving ROCK1, suggesting miR-145 as a potential new diagnostic and therapeutic target for the treatment of HCC | liver, |
| these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells | retinoblastoma, |
| Expression of both miR-145 and miR-10b was correlated with lymph node metastasis in NSCLC. miR-145 suppressed the migration and invasion capacity of A549 in vitro. miR-145 may act as a tumor suppressor gene in NSCLC metastasis. | lung, |