| Results support the recent notion that modulating the levels of miR-146a or miR-146b could have a therapeutic potential to suppress breast cancer metastasis. | breast, |
| miR-146a suppresses invasion of pancreatic cancer cells. | pancreatic, |
| miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1. | prostate, |
| miR-146a is a potential tumor suppressor gene in human neuroblastoma via directly targeting BCL11A | neuroblastoma, |
| miR-146a-5p displays the tumor suppressive role in non-small cell lung cancer cells. | lung, |
| These results suggest that miR-146a might function as a potent tumor suppressor in NKTL and be useful for patient assessment and therapeutic targeting. | None |
| Deregulation of miR-146 in many solid tumors and gene knockout studies indicate a role for this miRNA as a tumor suppressor. | None |
| Results suggest a potential tumor suppressive, immunomodulatory and cell activator role for miR-146-a. | None |
| The expression level of miR146a was higher and the expression of iNOS was lower in the GG/GC than in the CC group, suggesting the tumor suppressive effect of miR146a in RCC was mediated by its inhibitory effect on the expression of iNOS. | None |
| we identify miR-146a as a potential tumor suppressor in patients with EOC. miR-146a downregulates the expression of SOD2 and enhances ROS generation, leading to increased apoptosis, inhibition of proliferation, and enhanced sensitivity to chemotherapy. | None |
| Thus, the present study reveals a hitherto unknown tumour suppressive role for miR-146a providing a plausible mechanistic basis for it. | None |
| Authors identify miR-146a as a potential tumor suppressor in patients with EOC. miR-146a downregulates the expression of SOD2 and enhances ROS generation, leading to increased apoptosis, inhibition of proliferation, and enhanced sensitivity to chemotherapy. | None |
| miR-146a, serving as a tumor suppressor, may significantly promote GC cell apoptosis by inhibition of the NF-kappaB signaling pathway via targeting TAK1. | None |