| tumor suppressors, miR-15a are homozygously deleted in a subset of prostate cancers. | prostate, |
| These data suggest that miR-15a/16-1 may function as a tumor suppressor to regulate leukemic cell proliferation potentially by down-regulating the WT1 oncogene. | leukemia, |
| These findings suggest that miR-15a may act as a tumor suppressor gene in breast cancer and that, in the future, it could be used as a therapeutic target for the treatment of breast cancer. | breast, |
| miR-15a acts as a tumor suppressor in NSCLC by directly targeting BCL2L2 and may serve as a potential diagnostic biomarker and therapeutic target for NSCLC. | lung, |
| MiR-15a-5p selectively and negatively regulated BDNF at both gene and protein levels in HCC cells. Forced overexpression of BDNF effectively reversed the tumor suppressive functions of miR-15a-5p on HCC proliferation and cell division in vitro. | liver, |
| Study shows that miR-15a-3p is significantly downregulated in osteosarcoma, and this low expression level is closely associated with poor clinical outcomes among cancer patients. In addition, overexpressing miR-15a-3p had tumor suppressing effect on osteosarcoma cells. | osteosarcoma, |
| MiR-15 suppressed the progression of bladder cancer by targeting BMI1 oncogene via PI3K/AKT signaling pathway. | bladder, |
| The Oncogenic Kaposi_s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. | sarcoma, |
| c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster. | None |
| MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| MicroRNAs encoded by the miR-15/16 locus (miR-15 and miR-16) function as tumor suppressors. | None |
| This study provides new insights into the mechanism of cisplatin resistance due to silencing of the tumour suppressor hsa-miR-15a-3p and its possible contribution to apoptosis, autophagy and cisplatin resistance | None |
| miR-15a/16 may function as a tumor suppressor in MM through multiple regulatory mechanisms | None |
| BCL-2-related anti-apoptosis pathway was activated and the multidrug-resistant (MDR) genes LRP, MDR1 were up-regulated by LINC00473. Furthermore, inhibition of LINC00473 in vivo could overcome the Taxol resistance of CRC cells, could recover the expression of tumor suppressor miR-15a and chemotherapy-induced tumor regression, indicating that LINC00473 functioned as oncogene in CRC via miR-15a | None |