| These data suggest that miR-15a/16-1 may function as a tumor suppressor to regulate leukemic cell proliferation potentially by down-regulating the WT1 oncogene. | leukemia, |
| study reveals the progestin-regulated miRNA expression profile and identifies a novel role for miR-16 as a tumor suppressor in progestin- and growth factor-induced growth in breast cancer | breast, |
| The miR-15/16 family is downregulated and has tumour suppressor function in malignant pleural mesothelioma. | mesothelioma, |
| Validation of the important role of miR-16 as a tumor suppressor gene in glioma growth and invasiveness. | glioma, |
| c-Myc Represses Tumor-Suppressive microRNAs, let-7a, miR-16 and miR-29b, and Induces Cyclin D2-Mediated Cell Proliferation in Ewing_s Sarcoma Cell Line | sarcoma, |
| in vitro results showed that the repression of KRAS by miR-16 suppressed the proliferation and invasion and induced the apoptosis of colorectal cancer (CRC) cells, and the in vivo results revealed that miR-16 exerted a tumor-suppressive effect by negatively regulating KRAS in xenograft mice. Taken together, our findings provide evidence supporting the role of miR-16 as a tumor suppressor in CRC by targeting KRAS | colorectal, |
| Findings revealed that the miR16 functions as a tumor suppressor in glioblastoma multiforme stem cells. | glioblastoma, |
| miR-16 functions as a tumor suppressor miRNA to inhibit cell proliferation and induce apoptosis in oral squamous cell carcinoma through decreasing the oncogenes AKT3 and BCL2L2. | oral |
| Results found miRNA-16 downregulated in osteosarcoma (OS) and provide evidence that mir-16 acts as tumor suppressor and reduce metastasis in osteosarcoma. Boosting its expression sensitizes OS cells to chemotherapy. | osteosarcoma, |
| The Oncogenic Kaposi_s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family | sarcoma, |
| The Oncogenic Kaposi_s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. | sarcoma, |
| c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster. | None |
| MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| the role of miR-16 as a tumor suppressor by targeting IGF1R in OS | None |
| MicroRNAs encoded by the miR-15/16 locus (miR-15 and miR-16) function as tumor suppressors. | None |
| Our findings provide the first clues regarding the role of miR-16 as a tumor suppressor in cancer cells through the inhibition of FEAT translation. | None |
| The mRNA of TYRP1 is now found to sequester the tumour suppressor miR-16. | None |
| this data indicate that post-transcriptional repression of FGF-mediated signals contributes to the tumor suppressor function of the microRNA-15/16 family. | None |
| miR-16-5p plays a tumor suppressor role in chordoma progression by targeting Smad3. | None |