| miR-195 and miR-378 are abnormally expressed and epigenetically regulated in gastric cancer cell lines and tissues via the suppression of CDK6 and VEGF signaling, suggesting that miR-195 and miR-378 have tumor suppressor properties in gastric cancer. | gastric, |
| MiR-195-5p may act as a tumor suppressor in breast cancer. | breast, |
| findings indicated that miR-195 functions as tumour suppressor in NSCLC, and the miR-195/MYB axis might represent a potential therapeutic target for NSCLC intervention | lung, |
| our study demonstrated that miR-195 acts as a tumor suppressor by directly targeting CBX4 in hepatocellular carcinoma | liver, |
| Suggest that miR-195, a tumor suppressor miRNA, contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA expression. | liver,lung, |
| Tumor-suppressive microRNA-195-5p regulates cell growth and inhibits cell cycle by targeting cyclin dependent kinase 8 in colon cancer | colorectal, |
| A tumor suppressor role was found for miR-195-5p in osteosarcoma cells through inhibiting naked cuticle homolog 1. | osteosarcoma, |
| our findings show that microRNA-195 inhibits pancreatic cancer cell proliferation and invasion by regulating the fatty acid synthase/Wnt signaling pathway, suggesting a tumor suppressive role for microRNA-195 in the development and progression of pancreatic cancer. Thus, inhibiting fatty acid synthase by microRNA-195 may serve as a novel therapeutic approach for the treatment of pancreatic cancer. | pancreatic, |
| we identify the tripartite motif-containing protein (TRIM14) as a target of miR-195-5p. Therefore, we reason that the tumor suppressor role of miR-195-5p in oral squamous cell carcinoma is dependent on the interaction with TRIM14. | oral |
| MiR-195 is significantly downregulated in pancreatic cancer and plays tumor suppressor roles in inhibiting the proliferation, migration, and invasion of pancreatic cancer cells by negatively regulating DCLK1. | pancreatic, |
| MiRNA-195-5p Functions as a Tumor Suppressor and a Predictive of Poor Prognosis in Non-small Cell Lung Cancer by Directly Targeting CIAPIN1 | lung, |
| miR1955p acted as a tumor suppressor in squamous cell lung cancer (SQCLC) cells. The expression levels of miR195 were decreased in two SQCLC cell lines (H520 and SKMes1) compared with a normal lung cell line, and miR195 directly targeted the 3_untranslated region of vascular endothelial growth factor (VEGF) in SQCLC cells. | lung, |
| hese findings demonstrate that miR-195 and miR-497 act as a tumor suppressor by suppressing ubiquitination-mediated degradation of TGF-beta receptors through SMURF2, and suggest that miR-195 and miR-497 are potential therapeutic targets for lung cancer. | lung, |
| Correction to: MiRNA-195-5p Functions as a Tumor Suppressor and a Predictive of Poor Prognosis in Non-small Cell Lung Cancer by Directly Targeting CIAPIN1 | lung, |
| miR-195 Serves as a Tumor Suppressor in the Progression of Liposarcoma by Targeting OSBP | sarcoma, |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| MicroRNA-195 targets VEGFR2 and has a tumor suppressive role in ACHN cells via PI3K/Akt and Raf/MEK/ERK signaling pathways | None |
| Our results have suggested a tumor suppressive role for miR-195 in the tumorigenesis and progression of malignant meningioma by targeting FASN | None |