| miR-199a-5p can regulate CAC1 and function as a tumor suppressor in colorectal cancer. | colorectal, |
| MiR-199a-3p in glioma cell lines has effects similar to the tumor suppressor gene on cellular proliferation via the AKT/mTOR signaling pathway. | glioma, |
| miR-199a/b-3p functions as a tumor suppressor and has an important role in breast cancer metastasis through PAK4/MEK/ERK signaling pathway. | breast, |
| Microrna-199a-5p Functions as a Tumor Suppressor via Suppressing Connective Tissue Growth Factor (CTGF) in Follicular Thyroid Carcinoma | thyroid, |
| miR-199a-5p confers tumor-suppressive role in triple-negative breast cancer | breast, |
| these findings indicate that miR-199a acts as a tumour suppressor and its downregulation in tumour tissues may contribute to the progression and metastasis of Renal cell carcinoma (RCC) through a mechanism involving ROCK1, suggesting miR-199a as a potential new diagnostic and therapeutic target for the treatment of RCC. | kidney, |
| The putative tumor suppressor, miR-199a, regulated by Snail, modulates clear cell renal cell carcinoma aggressiveness by repressing ROCK1 | kidney, |
| Our work suggested that miR-199a-3p was related to cell growth, colony formation, cell invasion, cell migration and cell apoptosis, which might act as a tumor suppressor in clear cell renal cell carcinoma | colorectal,kidney, |
| miR199a5p functions as a tumor suppressor through regulation of the NFkappaB pathway by targeting IKKbeta in oral squamous cell carcinoma. | oral |
| miR-199a-3p is a major metabolic regulator in tumor suppression and miR-199a-3p may downregulate metabolic genes (LDHA, PGK1, MCT1, TIGAR) through the transcription factor Sp1. | None |
| our study identified miR-199a as a tumor suppressor in CRC cells both in vivo and in vitro. MicroRNA-199a-5p had proved to be suppressed in human CRCs and the reintroduction of it could be a potential method of suppressing the proliferation and progression of CRCs. | None |
| Up-regulated miR-199a-5p in gastric cancer functions as an oncogene and targets klotho. | gastric, |
| miR-199a-3p may function as a novel tumor promoter in gastric cancer and its oncogenic activity may involve the direct targeting and inhibition of ZHX1 | gastric, |
| Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-beta signalling pathway. | None |