| miR-200a appears to act as a multifunctional tumor suppressor miRNA in meningiomas through effects on the E-cadherin and Wnt/beta-catenin signaling pathways. | meningiomas, |
| Data suggest that miR-200 suppresses lung tumorigenesis by targeting Flt1. | lung, |
| a critical tumor suppressive role of the miR-200 family in breast epithelium in addition to identifying a novel regulatory mechanism, which may contribute to SIRT1 up-regulation in breast cancer | breast, |
| CDK6 was identified as a novel functional target of miR200a. Our data indicate that miR200a functions as a potential tumor suppressor in HCC. | liver, |
| Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family | colorectal, |
| miR-200a-3p is a suppressor miRNA in renal cell carcinoma due to its inactivation of the oncogenic activity of the novel target CBL. | kidney, |
| microRNA-200a functions as a tumor suppressor by targeting FOXA1 in glioma | glioma, |
| miR-200a-3p plays tumor suppressor roles in gastric cancer cells by targeting KLF12 | gastric, |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| We found upregulated miR-200a expression to increase E-cadherin and suppress the Wnt/beta-catenin pathway by targeting ZEB1 and ZEB2 in GA, thus delaying tumor growth in vivo. | None |
| miR-200a functions as an oncogene, affecting proliferation and apoptosis by regulating the expression of the tumor suppressor PTEN at the translational level. | None |