| miR-21 as an important oncogene that targets a network of p53, TGF-beta, and mitochondrial apoptosis tumor suppressor genes in glioblastoma cells. | glioblastoma, |
| human microRNA-21 (hsa-miR-21) showed a 4.4-fold higher expression in cholesteatoma as compared with normal skin/Identified up-regulation of hsa-miR-21 concurrent with down-regulation of potent tumor suppressor proteins PTEN and programmed cell death 4. | skin, |
| miR-21 directly inhibits the expression of thyroid hormone receptor beta (THRB), an important tumor suppressor gene, and inhibits thyroid hormone-THRB pathway | thyroid, |
| PDGF-B may enhance tumor proliferation by modulating the expression of oncomiRs and tumor suppressor miRNA-21 in U87 human GBM cells. | GBM, |
| MicroRNA-21-5p induces the metastatic phenotype of human cervical carcinoma cells in vitro by targeting the von Hippel-Lindau tumor suppressor | cervical, |
| Mir-21 is a putative oncogenic microRNA in Head and Neck Squamous Cell Carcinoma (HNSCC). | HNSC, |
| miR-21 as an important oncogene that targets a network of p53, TGF-beta, and mitochondrial apoptosis tumor suppressor genes in glioblastoma cells. | glioblastoma, |
| MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells. | glioblastoma, |
| Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells. | breast, |
| MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3. | cholangiocarcinoma, |
| Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. | laryngeal, |
| MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells. | cervical, |
| miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth. | prostate, |
| miR-21 may play an oncogenic role in the cellular processes of chronic myelogenous leukemia, and antisense inhibition of miR-21 may therefore be useful as CML therapy. | leukemia, |
| Antisense oligonucleotide against miR-21 inhibits migration and induces apoptosis in leukemic K562 cells. | leukemia, |
| MiR-21 might play a role as an oncogene in the tumorigenesis and development of ovarian epithelial carcinoma. | ovarian, |
| Studies indicate that loss of tumor suppressor miR-206, and the overexpression of oncogenic miR-21 have been observed in many breast cancers. | breast, |
| Among the proliferation class, miR-517a is an oncogenic miRNA that promotes tumor progression. There is rationale for developing therapies that target miR-517a for patients with HCC. | liver, |
| MicroRNA-based classification of hepatocellular carcinoma and oncogenic role of miR-517a. | liver, |
| A fusion transcript (RPS6KB1-VMP1) recurrently expressed in 30% of breast cancers is associated with clinical consequences and may indicate genomic instability altering the expression of oncogenic components such as MIR21 and RPS6KB1. | breast, |