| miR-21 may exert an oncogenic effect in melanoma by favouring redistribution of PTEN to the nucleus. | skin, |
| Inhibition of oncogenic miR-21 suppresses the growth of glioblastoma multiforme in vitro and in vivo. | glioblastoma, |
| miR-21-3p plays a crucial oncogenic role in cell metastasis during oral squamous cell carcinoma progression | oral |
| The reduced 15-PGDH may result in PGE2 accumulation which sustains carcinogenesis and tumor progression. We further found that miR-21 exert its oncogenic role through PGE2/PI3K/Akt/Wnt/beta-catenin axis in gastric cell proliferation. In conclusion, our findings enlarged our knowledge in the roles of miR-21 in the progression of gastric cancer. | gastric, |
| This study illustrated that miR-21 and miR-29a could be operated as an oncogene and tumor-suppressor in cervical cancer progression. | cervical, |
| miR-21-mediated tumor growth. | None |
| MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1). | None |
| Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. | None |
| MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. | None |
| MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene. | None |
| mir-21 functions as an oncogene by a mechanism that involves translational repression of the tumor suppressor Pdcd4 | None |
| An autoregulatory loop mediated by miR-21 and PDCD4 controls the AP-1 activity in RAS transformation. | None |
| results demonstrate that E(2) represses the expression of an oncogenic miRNA, miR-21, by activating estrogen receptor in MCF-7 cells. | None |
| Overexpression of miR-21 promotes an in vitro metastatic phenotype by targeting the tumor suppressor RHOB. | None |
| IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis. | None |
| Upregulation of miR-21 by Ras in vivo and its role in tumor growth. | None |
| MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4. | None |
| These data verified the oncogenic role of miR-21 in Transitional cell carcinomas | None |
| Col-1 up-regulated the expression of miR-21, a well-documented oncogenic microRNA, via a post-transcriptional mechanism | None |
| decorin prevented translational repression of PDCD4 by decreasing the activity of transforming growth factor-beta1 and the abundance of oncogenic miR-21, a translational inhibitor of PDCD4. | None |