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miR-221-3p targets PTEN mRNA and downregulates PTEN, which is the possible mechanism of miR-221-3p-induced oncogenic properties. Collectively, we reveal a critical role for miR-221-3p in gastric carcinoma development and progression.
gastric,
miR-221 has an oncogenic function in hepatocarcinogenesis by targeting CDKN1B/p27 and CDKN1C/p57, hence promoting proliferation by controlling cell-cycle inhibitors.
None
miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.
None
results suggest that miR-221/222 overexpression might be one of the factors contributing to oncogenesis and progression of atypical teratoid-rhabdoid tumors through p27Kip1 downregulation
None
miR-221 plays an oncogenic function in cutaneous squamous cell carcinoma by targeting PTEN.
None
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