| Hsp90B1 is a direct target of miR-223 and miR- 223 may have a tumor suppressor function in osteosarcoma through the PI3K/Akt/mTOR pathway. | osteosarcoma, |
| miR-223 functions as a tumor suppresser in osteosarcoma and miR-223/Ect2/p21 signaling is an important pathway that regulates the osteosarcoma cell cycle progression and proliferaion | osteosarcoma, |
| miR-223 functions as a tumor suppressor in osteosarcoma and miR-223/Ect2/p21 signaling is an important pathway that regulates the osteosarcoma cell cycle progression and proliferaion | osteosarcoma, |
| Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer | prostate, |
| miR-223 functions as a tumor suppressor and plays a critical role in inhibiting the tumorigenesis and promoting the apoptosis of HCC through the mTOR signaling pathway in vitro | liver, |
| Overexpression of miR-223 in GBM cells markedly decreased temozolomide-induced inhibition of cell proliferation and increased temozolomide inhibitory concentration 50, which could be abolished by overexpression of tumor suppressor paired box 6. | GBM, |
| Tumor?suppressive microRNA?223 targets WDR62 directly in bladder cancer | bladder, |
| Abundant evidences suggest that miR-223 acts as a crucial regulator in various cancers, mainly through its targeting of related genes and interactions with several signaling pathways. It can function as a tumor suppressor or promoter and is involved in an aboard range of cancer cellular processes, including cell proliferation, apoptosis, differentiation, metastasis and invasion. [review] | None |
| miRNA-223 promotes gastric cancer invasion and metastasis by targeting tumor suppressor EPB41L3. | gastric, |
| MicroRNA-223 functions as an oncogene in human gastric cancer by targeting FBXW7/hCdc4. | gastric, |
| miR-223 has a role in regulating cell growth and targets proto-oncogenes in mycosis fungoides/cutaneous T-cell lymphoma | lymphoma, |
| MicroRNA-223 functions as an oncogene in human colorectal cancer cells. | colorectal, |
| Our findings suggest an oncogenic role for miR2233p in testicular germ cell tumor, which promotes cell growth and inhibits apoptosis through repression of FBXW7. | testicular, |
| both strands of the miR-223-duplex, miR-223-5p (the passenger strand), and miR-223-3p (the guide strand), acted as anti-tumor miRNAs through their targeting of several oncogenic genes in BC cells. | None |
| miR-223 expression was higher in OSCC and acted as an oncogene in the development of OSCC. We also found the target gene of miR-223 in regulating of OSCC cell proliferation and migration was FBXW7. | None |