| miR-26b may act as a tumor suppressor in glioma and it directly regulates EphA2 expression | glioma, |
| A binding site for miR-26b was predicted in the 3_UTR of PFKFB3, suggesting a tumor suppressive role for miR-26b in metabolic alteration in osteosarcoma cells. miR-26b overexpression repressed PFKFB3 mRNA and protein levels. | osteosarcoma, |
| Data showed downregulation of miR-26a and miR-26b in prostate cancer and suggested them as tumor suppressors. They both targeted the 3_UTR of LARP1. | prostate, |
| Tumor-suppressive microRNAs (miR-26a/b, miR-29a/b/c and miR-218) concertedly suppressed metastasis-promoting LOXL2 in head and neck squamous cell carcinoma | HNSC, |
| Results show that miR-26a and miR-26b were significantly downregulated in renal cell carcinoma clinical specimens and appeared to function as tumor suppressors through regulation of collagen cross-linking enzymes, LOXL2 and PLOD2, both of which function as oncogenes in this disease. | kidney, |
| Tumor-suppressive miR-26a and miR-26b inhibit cell aggressiveness by regulating FUT4 in colorectal cancer | colorectal, |
| Studies show that elevated expression of miR-26b promotes invasiveness, migration, and a stem cell-like phenotype in colorectal cancer by simultaneously suppressing the tumor suppressors PTEN and WNT5A. | colorectal, |
| miR-26b might have a tumor suppressive role in oral squamous cell carcinoma. | oral |
| Results found that miR-26b expression was decreased in nasopharyngeal carcinoma tissues, and LINC00520 facilitated tumor cell proliferation in vitro via sponging miR-26b. Further data demonstrated miR-26b functioned as a tumor suppressor on NPC by directly targeting USP39. | nasopharyngeal,laryngeal, |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| MiR-26b may serve as a tumor suppressor by targeting Nampt. | None |
| miR-26b serves as a tumor suppressor by targeting COX-2 | None |
| MiR-26b-5p acts as a tumor suppressor through suppressing cells proliferation and inducing cells apoptosis via directly targeting JAG1 in multiple myeloma | None |