| miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway | None |
| miR-34a functions as a tumor suppressor in RB cells and is a potential therapeutic target. | None |
| miR-34a is a tumor suppressor. | None |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| miR-34a presumably participates in multiple tumor suppressive pathways by directly and indirectly suppressing the expression of numerous, critical proteins. | None |
| Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling. | None |
| ZEB1 controls the expression of numerous oncogenic and tumor-suppressive miRs, including miR-34a | None |
| Results suggest that miR-34 controls a tumor suppressor pathway previously reserved for TP53 and provides an attractive therapeutic strategy for cancer patients irrespective of TP53 status. | None |
| our study demonstrated that miR-34c plays a role of tumor suppressor in HEC-1-B cells, and E2F3 protein may be a target of miR-34c. | None |
| results suggest that miR-34a and miR-335 are candidate tumor suppressive miRNAs in GISTs, and that they are frequent targets of epigenetic silencing in GISTs. | None |
| The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels | None |
| The tumor-suppressive and potential therapeutic functions of miR-34a in epithelial carcinomas | None |
| analysis of the endogenous miR-34A-p53 tumor suppressor network | None |
| Tumor suppressor miRNAs such as miR-34a inhibit tumor growth by simultaneously regulating the expression of multiple important oncogenes across multiple oncogenic pathways and, therefore, provide a strong rationale for developing therapeutic miRNA mimics in combination with other therapeutic cancer agents to augment drug sensitivity. Here, we describe the experimental approach for evaluating miRNA and drug combinations | None |
| Identification of targets of tumor suppressor microRNA-34a using a reporter library system | None |
| An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a | None |
| A combined experimental and computational study on peptide nucleic acid (PNA) analogues of tumor suppressive miRNA-34a | None |
| Identification of miPEP133 as a novel tumor-suppressor microprotein encoded by miR-34a pri-miRNA#This is the parental gene. | None |
| MiR-34a targets GAS1 to promote cell proliferation and inhibit apoptosis in papillary thyroid carcinoma via PI3K/Akt/Bad pathway. | thyroid, |
| results demonstrate that miR-34a regulates GAS1 expression to promote proliferation and suppress apoptosis in papillary thyroid carcinoma (PTC) cells via PI3K/Akt/Bad pathway. MiR-34a functions as an oncogene in PTC. | thyroid, |