Showing 41-45 of 45 items.

Sentence	Cancertype
miR-34a is an oncogenic miRNA, downregulated in the distinct breast cancer subtypes. It also targets MET and AXL 3_-UTRs in triple-negative breast cancer.	breast,
MiR-34a acts as a tumor-suppressor gene by targeting many oncogenes related to proliferation, apoptosis and invasion. [review]	None
underexpression of miR-34a may play a role in the oncogenesis of MCV-negative tumors	None
Tumor suppressor miRNAs such as miR-34a inhibit tumor growth by simultaneously regulating the expression of multiple important oncogenes across multiple oncogenic pathways and, therefore, provide a strong rationale for developing therapeutic miRNA mimics in combination with other therapeutic cancer agents to augment drug sensitivity. Here, we describe the experimental approach for evaluating miRNA and drug combinations	None
results demonstrate that miR-34a directly targets tRNAi(Met) precursors via AGO2-mediated cleavage, and that tRNAi(Met) functions as an oncogene, potentially representing a target molecule for therapeutic intervention.	None