| miR-34b/c and BTG4 are novel tumor suppressors in colorectal cancer (CRC) and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC | colorectal, |
| miR-34b/c is a candidate tumor suppressor that is epigenetically silenced in chronic lymphocytic leukemia. | leukemia, |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| MicroRNA-34b has an oncogenic role in esophageal squamous cell carcinoma. | esophageal, |
| The results indicated that Notch1 and its target genes, Hes family BHLH transcription factor 1 and Hesrelated family BHLH transcription factor with YRPW motif 1, were suppressed by miR34b directly In conclusion, EWSFLI1 may modulate miR34b expression directly or indirectly, and miR34b potentially has an oncogenic role in Ewing_s sarcoma by downregulating Notch1. | sarcoma, |