| miR-34b/c and BTG4 are novel tumor suppressors in colorectal cancer (CRC) and that the miR-34b/c CpG island, which bidirectionally regulates miR-34b/c and BTG4, is a frequent target of epigenetic silencing in CRC | colorectal, |
| miR-34c is downregulated in prostate cancer and exerts tumor suppressive functions. | prostate, |
| miR-34b/c is a candidate tumor suppressor that is epigenetically silenced in chronic lymphocytic leukemia. | leukemia, |
| Results support the role of miR-34c as a tumor suppressor miRNA in breast cancer. | breast, |
| miR-34c is a putative tumor suppressor in high-grade serous ovarian carcinoma with potential therapeutic advantages. | ovarian, |
| miR-34c may act as a potential tumor suppressor gene in lung adenocarcinomas. | lung, |
| Comparative expression analysis revealed lower expression of miR-34c in precancerous cervical epithelium than in normal untransformed epithelium. in vitro modulation of miR-34c expression revealed its tumor suppressor role in cervical malignancies. | cervical, |
| MiR-34c acts as a tumor suppressor in non-small cell lung cancer by inducing endoplasmic reticulum stress through targeting HMGB1 | lung, |
| This study, we performed a comprehensive analysis of putative human miRNA oncogenes and tumor suppressors. We found that miRNA oncogenes and tumor suppressors clearly show different patterns in function, evolutionary rate, expression, chromosome distribution, molecule size, free energy, transcription factors, and targets. | None |
| These results suggest differential tumor suppressor roles for miR-34c-3p and miR-34c-5p and provide new insights in the understanding of miRNA biology. | None |
| These data suggested that miR34c3p acts as a tumor suppressor via regulation of MARCKS expression in OS progression | None |
| that miR-34c and miR-613 could reverse the oncogenic function of differentiation antagonizing non-protein coding RNA in retinoblastoma tumorigenesis | retinoblastoma, |