| MBD1 may be a tumor suppressor gene in advanced colorectal cancer (CRC)and affect the development and metastasis of CRC by regulating 8 tumor suppressor genes through binding with SP1. | colorectal, |
| Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin. | pancreatic, |
| higher MBD1 expression correlated with lymph node metastasis and poor survival in pancreatic cancer; gain- and loss-of-function studies in vitro validated MBD1 as a potent oncogene promoting pancreatic cancer cell invasion and epithelial-mesenchymal transition | pancreatic, |