Sentence and cancer type
Showing 61-80 of 180 items.
SentenceCancertype
The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2. None
Expression of mdm-2 oncoprotein in the primary and metastatic sites of mammary tumor (GI-101) implanted athymic nude mice. None
Cloning, sequence analysis and expression of the cDNAs encoding the canine and equine homologues of the mouse double minute 2 (mdm2) proto-oncogene. None
MDM2 oncogene as a novel target for human cancer therapy. None
Sequence-specific 1H, 15N, and 13C assignment of the N-terminal domain of the human oncoprotein MDM2 that binds to p53. None
Multiple sites of in vivo phosphorylation in the MDM2 oncoprotein cluster within two important functional domains. None
A modified p53 overcomes mdm2-mediated oncogenic transformation: a potential cancer therapeutic agent. None
Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53. None
Stabilization of the MDM2 oncoprotein by mutant p53. None
The human oncoprotein MDM2 uses distinct strategies to inhibit transcriptional activation mediated by the wild-type p53 and its tumor-derived mutants. None
Preferential expression of Mdm2 oncogene during the development of neural crest and its derivatives in mouse early embryogenesis. None
Fragments of human oncoprotein MDM2 reveal variable distribution within and on cultivated human hepatoma cells. None
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63. None
Genetic analysis of the human oncoprotein MDM2 in benign and malignant tumors of the salivary gland. None
Function and dysfunction of the human oncoprotein MDM2. None
Normal cells may induce full-length MDM2 in response to oncogenic challenges to protect against premature cell cycle progression. MDM2 is regulated by p53 especially durnig embryogenesis where MDM2 function is inhibited.None
Transcriptional regulation of the mdm2 oncogene by p53 requires TRRAP acetyltransferase complexes. None
MDM2 has been characterized as a protein that binds to and facilitates degradation of the tumor suppressor p53. Splice variants of MDM2 transcripts have been identified in both tumors and normal tissues.None
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. None
Characterization of two peptide epitopes on Mdm2 oncoprotein that affect p53 degradation. None