Sentence and cancer type
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SentenceCancertype
The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3. leukemia,
data identify ENL as a histone acetylation reader that regulates oncogenic transcriptional programs in acute myeloid leukaemia, and suggest that displacement of ENL from chromatin may be a promising epigenetic therapy, alone or in combination with BET inhibitors, for aggressive leukaemiaNone